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NecroX-7

NecroX-7

产品编号 T9948   CAS 1120332-55-9
别名: LC-280126, LC28-0126, LC28 0126

NecroX-7 (LC-280126) 是一种有效的自由基清除剂和 HMGB1(高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的 TNF 和 IL-6的释放,以及TLR-4和晚期糖基化终产物受体的表达,用于移植物抗宿主病 (GVHD) 研究。

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NecroX-7 Chemical Structure
NecroX-7, CAS 1120332-55-9
规格 价格/CNY 货期 数量
1 mg ¥ 497 现货
5 mg ¥ 1,230 现货
10 mg ¥ 1,980 现货
25 mg ¥ 4,570 现货
50 mg ¥ 7,870 现货
产品目录号及名称: NecroX-7 (T9948)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 may be use for treatment of graft-versus-host disease (GVHD) research [1].
体外活性 NecroX-7 (0-40 μM, 3-4 d) inhibits activated or proliferating T cells without causing apoptosis [1]. NecroX-7 (0-40 μM) significantly lowers HMGB1 levels in a dose-dependent manner [1]. NecroX-7 inhibits formation of mitochondria-specific ROS/reactive nitrogen species in H9C2 cells and hepatocytes after induction by tert-butyl hydroperoxide or doxorubicin [1]. NecroX-7 increased regulatory T cell numbers, which may be associated with regulation of differentiation signals independent of HMGB1 [1]. Cell Proliferation Assay [1] Cell Line: CD4 T cells Concentration: 0, 0.625, 1.25, 2.5, 5, 10, 20, and 40 μM Incubation Time: 3-4 d Result: Showed a marked reduction in splenocyte proliferation, in a dose-dependent manner. Modulated alloreactive T cell responses.
体内活性 NecroX-7 (0-0.3 mg/kg, IV, once injection at 2-d intervals, for 2 weeks) markedly reduces GVHD-related mortality and inhibits severe tissue damage [1]. NecroX-7 protects mice against lethal GVHD by reciprocal regulation of regulatory T/Th1 cells, attenuating systemic HMGB1 accumulation and inhibiting HMGB1-mediated inflammatory response [1]. Animal Model: Female BALB/c and C57BL/6 mice (Eight-week-old, with GVHD) [1] Dosage: 0.03, 0.1, and 0.3 mg/kg Administration: IV, once injection at 2-d intervals, for 2 weeks Result: Observed statistically significant prolonged survival at doses ≥0.1 mg/kg: 30–60% of mice in these treatment groups survived for >50 d. Significantly improved clinical signs and prolonged survival, and the mice showed a reduction in clinical manifestations of acute GVHD, including weight loss, hunched posture, diarrhea, and ruffled fur.
别名 LC-280126, LC28-0126, LC28 0126
分子量 439.57
分子式 C24H29N3O3S
CAS No. 1120332-55-9

存储

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Grootaert MOJ, et al. NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice. Atherosclerosis. 2016 Sep;252:166-174. 2. Park J, et al. NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats. Toxicol Appl Pharmacol. 2012 Aug 15;263(1):1-6.
ML-090 Totaradiol APX-115 free base Zederone Neoechinulin A 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate gp91ds-tat (R)-Reticuline

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
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动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
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计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

NecroX-7 1120332-55-9 Immunology/Inflammation NADPH-oxidase LC 280126 NecroX7 LC-280126 NecroX 7 LC28-0126 LC280126 LC28 0126 Inhibitor inhibitor inhibit

 

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