Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 3,290 | 5日内发货 | ||
5 mg | ¥ 5,390 | 5日内发货 | ||
25 mg | ¥ 11,700 | 6-8周 | ||
50 mg | ¥ 15,300 | 6-8周 | ||
100 mg | ¥ 19,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 7,260 | 5日内发货 |
产品描述 | NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM). |
靶点活性 | PPARγ (human):15 μM, GR:32.5 μM, ERβ:15.2 μM, PPARδ (human):6 μM, PPARα (human):77 nM |
体外活性 | NXT629 is a potent and selective antagonist of PPAR-α(human PPARα,IC50 of 77 nM), shows high selectivity over other nuclear hormone receptor, [2]. |
体内活性 | NXT629 has poor oral bioavailability in mice and rats.?NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice.?NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis.?NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung[2]. |
分子量 | 609.78 |
分子式 | C35H39N5O3S |
CAS No. | 1454925-59-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (204.99 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6399 mL | 8.1997 mL | 16.3994 mL | 40.9984 mL |
5 mM | 0.328 mL | 1.6399 mL | 3.2799 mL | 8.1997 mL | |
10 mM | 0.164 mL | 0.82 mL | 1.6399 mL | 4.0998 mL | |
20 mM | 0.082 mL | 0.41 mL | 0.82 mL | 2.0499 mL | |
50 mM | 0.0328 mL | 0.164 mL | 0.328 mL | 0.82 mL | |
100 mM | 0.0164 mL | 0.082 mL | 0.164 mL | 0.41 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NXT629 1454925-59-7 Endocrinology/Hormones Estrogen/progestogen Receptor NXT 629 NXT-629 Inhibitor inhibitor inhibit