Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC 370284 是一种小分子,可直接结合并抑制 STAT3/5,在体外和体内显着选择性地抑制具有高水平 TET1 表达的 AML 细胞的活力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 261 | 现货 | ||
5 mg | ¥ 657 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,650 | 现货 | ||
50 mg | ¥ 3,950 | 现货 | ||
100 mg | ¥ 5,630 | 现货 | ||
500 mg | ¥ 11,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 726 | 现货 |
产品描述 | NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
体外活性 | NSC-370284 exhibited the most significant effects in inhibiting cell viability of all four TET1-high AML cell lines, whereas showing no significant inhibition on viability of NB4/t(15;17) AML cells [1].The direct binding of STAT3 and STAT5 on the TET1 loci was further validated in MONOMAC-6 cells, and such binding could be disturbed by NSC-370284 treatmen [1].Analysis suggested a potential direct binding of NSC-370284 to the conserved DNA-binding domain (DBD) of STAT3 or STAT5 [1]. |
体内活性 | NSC 370284 treatments significantly inhibited MLL-AF9-induced AML in secondary bone marrow transplantation (BMT) recipient mice, and 57% (4 out of 7) of the NSC-370284-treated mice were cured, as the pathological morphologies in peripheral blood (PB), BM, spleen, and liver tissues all turned to normal. [1] |
分子量 | 387.43 |
分子式 | C21H25NO6 |
CAS No. | 116409-29-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (141.96 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5811 mL | 12.9056 mL | 25.8111 mL | 64.5278 mL |
5 mM | 0.5162 mL | 2.5811 mL | 5.1622 mL | 12.9056 mL | |
10 mM | 0.2581 mL | 1.2906 mL | 2.5811 mL | 6.4528 mL | |
20 mM | 0.1291 mL | 0.6453 mL | 1.2906 mL | 3.2264 mL | |
50 mM | 0.0516 mL | 0.2581 mL | 0.5162 mL | 1.2906 mL | |
100 mM | 0.0258 mL | 0.1291 mL | 0.2581 mL | 0.6453 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NSC 370284 116409-29-1 JAK/STAT signaling Stem Cells STAT NSC-370284 NSC370284 Inhibitor inhibitor inhibit