Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,150 | 5日内发货 | ||
50 mg | ¥ 5,310 | 6-8周 | ||
100 mg | ¥ 8,230 | 6-8周 |
产品描述 | NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp). |
体外活性 | NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. SKOV-3 cells with long-term exposure of 1 μM NSC23925 display stable growth in the culture medium. However, the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3TR or OVCAR8TR to cytotoxic drugs is 0.5 μM to 1 μM. The IC50 for NSC23925 is 8 μM in SKOV-3/SKOV-3TR and 25 μM in OVCAR8/OVCAR8TR cell lines. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 μM [1][2]. |
体内活性 | The usage of NSC23925 significantly prolongs the anticancer efficacy of paclitaxel in paclitaxel chemotherapy. Both saline alone and NSC23925 alone treated tumors grow progressively [1]. |
分子量 | 421.36 |
分子式 | C22H26Cl2N2O2 |
CAS No. | 858474-14-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NSC23925 858474-14-3 Immunology/Inflammation Nrf2 NSC-23925 NSC 23925 Inhibitor inhibitor inhibit