Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.
产品描述 | NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption. |
体外活性 | NP213 is against T. rubrum NCPF0118, which shows different MIC values against T. rubrum NCPF0118, and the MICs vary depending on the source of the keratin. NP213 (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus app, and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 μg/ml. NP213 (500-1000 μg/mL; 18 hours) enhances the number of PI-stained T. rubrum NCPF0118 cells in samples. These results shows that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin, and Lamb's wool Keratin, respectively[1][3]. |
体内活性 | NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h, in Murine models of acute disseminated candidiasis. NP213 (25 mg/kg) is well tolerated in mice [3]. |
分子量 | 1093.3 |
分子式 | C42H84N28O7 |
CAS No. | 942577-31-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NP213 942577-31-3 Chromatin/Epigenetic Epigenetic Reader Domain NP 213 NP-213 Inhibitor inhibitor inhibit