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NP213

NP213

产品编号 TP2149L   CAS 942577-31-3

NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.

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NP213 Chemical Structure
NP213, CAS 942577-31-3
规格 价格/CNY 货期 数量
100 mg 待询 待询
500 mg 待询 待询
产品目录号及名称: NP213 (TP2149L)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.
体外活性 NP213 is against T. rubrum NCPF0118, which shows different MIC values against T. rubrum NCPF0118, and the MICs vary depending on the source of the keratin. NP213 (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus app, and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 μg/ml. NP213 (500-1000 μg/mL; 18 hours) enhances the number of PI-stained T. rubrum NCPF0118 cells in samples. These results shows that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin, and Lamb's wool Keratin, respectively[1][3].
体内活性 NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h, in Murine models of acute disseminated candidiasis. NP213 (25 mg/kg) is well tolerated in mice [3].
分子量 1093.3
分子式 C42H84N28O7
CAS No. 942577-31-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Mercer DK,et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02117-18 2. Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins. 2016 Jun;8(2):85-101. 3. Novamycin®/NP339 Technology Summary
CBP/p300-IN-2 BRD4 Inhibitor-20 (R)-(-)-JQ1 Enantiomer J-147 3',6-Disinapoylsucrose CPI-203 C-82 A-366

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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

NP213 942577-31-3 Chromatin/Epigenetic Epigenetic Reader Domain NP 213 NP-213 Inhibitor inhibitor inhibit

 

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