Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NIH12848 是推定的磷脂酰肌醇 5-磷酸4-激酶 γ (PI5P4Kγ) 抑制剂(IC50:1 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 297 | 现货 | ||
2 mg | ¥ 442 | 现货 | ||
5 mg | ¥ 697 | 现货 | ||
10 mg | ¥ 987 | 现货 | ||
25 mg | ¥ 1,980 | 现货 | ||
50 mg | ¥ 2,950 | 现货 | ||
100 mg | ¥ 4,260 | 现货 | ||
500 mg | ¥ 8,980 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 722 | 现货 |
产品描述 | NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM. |
靶点活性 | PI5P4Kγ:1 μM |
体外活性 | NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes' on the culture dish. NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks. |
分子量 | 385.41 |
分子式 | C20H14F3N3S |
CAS No. | 959551-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (142.71 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5946 mL | 12.9732 mL | 25.9464 mL | 64.866 mL |
5 mM | 0.5189 mL | 2.5946 mL | 5.1893 mL | 12.9732 mL | |
10 mM | 0.2595 mL | 1.2973 mL | 2.5946 mL | 6.4866 mL | |
20 mM | 0.1297 mL | 0.6487 mL | 1.2973 mL | 3.2433 mL | |
50 mM | 0.0519 mL | 0.2595 mL | 0.5189 mL | 1.2973 mL | |
100 mM | 0.0259 mL | 0.1297 mL | 0.2595 mL | 0.6487 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NIH-12848 959551-10-1 PI3K/Akt/mTOR signaling PI3K Inhibitor NIH 12848 NIH12848 inhibit inhibitor