Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NAMI-A 是一种钌基化合物,具有抗肿瘤转移的选择性活性。NAMI-A 可抑制癌细胞粘附和迁移。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 813 | 现货 | ||
5 mg | ¥ 1,980 | 现货 | ||
10 mg | ¥ 2,890 | 现货 | ||
25 mg | ¥ 4,730 | 现货 | ||
50 mg | ¥ 6,590 | 现货 | ||
100 mg | ¥ 8,890 | 现货 |
产品描述 | NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration. |
体外活性 |
NAMI-A can significantly affect tumor cells with metastatic ability. The half-life of NAMI-A elimination from the lungs is longer than for the liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations.[1] The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.[2] |
分子量 | 458.18 |
分子式 | C8H15Cl4N4ORuS |
CAS No. | 201653-76-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 8.28 mg/mL (18.07 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 2.1825 mL | 10.9127 mL | 21.8255 mL | 54.5637 mL |
5 mM | 0.4365 mL | 2.1825 mL | 4.3651 mL | 10.9127 mL | |
10 mM | 0.2183 mL | 1.0913 mL | 2.1825 mL | 5.4564 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NAMI-A 201653-76-1 Angiogenesis Cytoskeletal Signaling Metabolism Tyrosine Kinase/Adaptors FAK CETP NAMIA NAMI A Inhibitor inhibitor inhibit