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N-Carbethoxy-4-piperidone

产品编号 T1340 CAS 29976-53-2

N-Carbethoxy-4-piperidone 是一种aminopyrimidine 衍生物，含有它们的组合物被用作药物。

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N-Carbethoxy-4-piperidone Chemical Structure

N-Carbethoxy-4-piperidone, CAS 29976-53-2

规格	价格/CNY		货期	数量
1 g	￥ 164		现货
1 mL * 10 mM (in DMSO)	￥ 195		现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.

激酶实验

A crude cell-free extract is isolated from LI 210 cells in culture by suspension of the cells in a given volume of 0.05mol/LTris-HCl buffer, pH 7.4, and sonic extraction with a Biosonik at 70% maximal output for 30 sec. The supernatant is collected after centrifugation at 105,000 × g for 60 min (4°C) in a Model L Spinco ultracentrifuge. The final protein concentration of the cell-free extracts is approximately 3 mg/mL. The extracts are used as the source of enzymes. Ribonucleotide reductase activity is measured. A unit of enzyme is defined as the amount that catalyzed dCMP synthesis at a rate of 1 mμmole/hr. The assay systems for the measurement of pyrimidine nucleoside (CR) and deoxynucleoside (TdR, CdR) kinases are essentially those described by Chu and Fischer. However, reactions are terminated by heating for 2 min in a boiling water bath, and the phosphorylated derivatives are isolated according to the method of Bach. Fifty-jul aliquots are applied to 1-inch discs of diethylaminoethyl paper, which are then placed in counting vials and eluted with 0.5 mL of 0.5 mol/LPCA. After 1 hr, 12 mL of Diotol are added, and the radioactivity is determined.

分子量	171.19
分子式	C8H13NO3
CAS No.	29976-53-2

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 60 mg/mL (350.48 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.8415 mL	29.2073 mL	58.4146 mL	146.0366 mL
	5 mM	1.1683 mL	5.8415 mL	11.6829 mL	29.2073 mL
	10 mM	0.5841 mL	2.9207 mL	5.8415 mL	14.6037 mL
	20 mM	0.2921 mL	1.4604 mL	2.9207 mL	7.3018 mL
	50 mM	0.1168 mL	0.5841 mL	1.1683 mL	2.9207 mL
	100 mM	0.0584 mL	0.2921 mL	0.5841 mL	1.4604 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Eric Gundersen et al.Bioorganic & Medicinal Chemistry Letters, 15(7), 1891-1894 (2005)

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

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μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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