Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 3,740 | 5日内发货 |
Motixafortide 的其他形式现货产品:
产品描述 | Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). |
靶点活性 | CXCR4:1 nM |
体外活性 | Motixafortide (BKT140) displays selective toxicity toward AmL and MM cells. Motixafortide (BKT140) specifically triggers CXCR4-dependent cell death in leukemia and MM cells and it stimulates apoptotic cell death in leukemia and MM cells[2]. Treatment with Motixafortide (BKT140) can overcome IL-6 dependent proliferation and survival of ARH77 MM cells. |
体内活性 | Tumors from animals treated with Motixafortide (BKT140) are smaller in size and weights, had larger necrotic areas and high apoptotic scores[2]. Subcutaneous injections of Motixafortide (BKT140) significantly reduces, in a dose-dependent manner, the growth of human acute myeloid leukemia and multiple myeloma xenografts. |
别名 | BL-8040, BKT140 (4-fluorobenzoyl), TF14016 |
分子量 | 2159.52 |
分子式 | C97H144FN33O19S2 |
CAS No. | 664334-36-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36 mg/mL (16.67 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.4631 mL | 2.3153 mL | 4.6307 mL | 11.5766 mL |
5 mM | 0.0926 mL | 0.4631 mL | 0.9261 mL | 2.3153 mL | |
10 mM | 0.0463 mL | 0.2315 mL | 0.4631 mL | 1.1577 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Motixafortide 664334-36-5 Autophagy GPCR/G Protein Immunology/Inflammation CXCR BL8040 BL-8040 BL 8040 4-fluorobenzoyl TF-14016 TF 14016 BKT 140 BKT140 (4-fluorobenzoyl) TF14016 BKT140 BKT-140 Inhibitor inhibitor inhibit