Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mitochonic acid 5 (MA-5) 能够调节线粒体 ATP 合成,可与线粒体结合,并改善肾小管和心肌细胞损伤。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 401 | 现货 | ||
5 mg | ¥ 1,080 | 现货 | ||
10 mg | ¥ 1,890 | 现货 | ||
25 mg | ¥ 3,820 | 现货 | ||
50 mg | ¥ 5,550 | 现货 | ||
100 mg | ¥ 7,770 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,180 | 现货 |
产品描述 | Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases. |
体外活性 | Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis[1]. |
细胞实验 | TNFα was used to induce inflammatory injury in mouse microglial BV-2 cells with and without prior MA-5 treatment. Cellular apoptosis was assessed using the MTT and TUNEL assays. Mitochondrial functions were evaluated via mitochondrial membrane potential JC-1 staining, ROS flow cytometry analysis, mPTP opening assessment, and immunofluorescence of cyt-c. Mitophagy was examined using western blots and immunofluorescence. The pathways analysis was carried out using western blots and immunofluorescence with a pathway blocker[1]. |
别名 | MA-5 |
分子量 | 329.3 |
分子式 | C18H13F2NO3 |
CAS No. | 1354707-41-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (288.49 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0367 mL | 15.1837 mL | 30.3674 mL | 75.9186 mL |
5 mM | 0.6073 mL | 3.0367 mL | 6.0735 mL | 15.1837 mL | |
10 mM | 0.3037 mL | 1.5184 mL | 3.0367 mL | 7.5919 mL | |
20 mM | 0.1518 mL | 0.7592 mL | 1.5184 mL | 3.7959 mL | |
50 mM | 0.0607 mL | 0.3037 mL | 0.6073 mL | 1.5184 mL | |
100 mM | 0.0304 mL | 0.1518 mL | 0.3037 mL | 0.7592 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mitochonic acid 5 1354707-41-7 Metabolism Mitochondrial Metabolism Inhibitor MA 5 Mitochonic acid5 Mitochonic acid-5 MA-5 MA5 inhibit inhibitor