Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mirodenafil dihydrochloride 是一种磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 185 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 1,230 | 现货 | ||
50 mg | ¥ 1,990 | 现货 | ||
100 mg | ¥ 3,190 | 现货 | ||
500 mg | ¥ 6,920 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 549 | 现货 |
产品描述 | Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
体内活性 | Mirodenafil, in doses of 50 or 100 mg, significantly improved erectile function and was well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities [1]. The concurrent administration of mirodenafil with alcohol was not associated with clinically significant hemodynamic changes in these healthy male volunteers in Korea. The pharmacokinetics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil administered with alcohol had a tolerability profile comparable to that of mirodenafil alone [2]. |
别名 | SK-3530 dihydrochloride, 米罗那非二盐酸盐 |
分子量 | 604.59 |
分子式 | C26H39Cl2N5O5S |
CAS No. | 862189-96-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (165.40 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.654 mL | 8.2701 mL | 16.5401 mL | 41.3503 mL |
5 mM | 0.3308 mL | 1.654 mL | 3.308 mL | 8.2701 mL | |
10 mM | 0.1654 mL | 0.827 mL | 1.654 mL | 4.135 mL | |
20 mM | 0.0827 mL | 0.4135 mL | 0.827 mL | 2.0675 mL | |
50 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.827 mL | |
100 mM | 0.0165 mL | 0.0827 mL | 0.1654 mL | 0.4135 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mirodenafil dihydrochloride 862189-96-6 Metabolism PDE Inhibitor Wnt Beta catenin SK-3530 dihydrochloride Mirodenafil Dihydrochloride MRC-5 cells SK3530 Dihydrochloride Glucocorticoid Receptor Phosphodiesterase (PDE) NIH3T3 erectile dysfunction Alzheimer’s disease inhibit SK 3530 SH-SY5Y 米罗那非二盐酸盐 Mirodenafil SK-3530 SK-3530 Dihydrochloride β-catenin systemic sclerosis SK 3530 Dihydrochloride Apoptosis HT-22 cells SK3530 fibrosis inhibitor