Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Miglitol (BAY1099) 是一种口服抗糖尿病化合物,能够抑制糖复合体分解为葡萄糖。
产品描述 | Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity. |
体内活性 | D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice. [1] D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age. [2] D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls. [3] D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. [4] D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. [5] |
别名 | BAY1099, 米格列醇, BAY-m1099 |
分子量 | 207.22 |
分子式 | C8H17NO5 |
CAS No. | 72432-03-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20.7 mg/mL (100 mM)
DMSO: 20.7 mg/mL (100 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 4.8258 mL | 24.1289 mL | 48.2579 mL | 120.6447 mL |
5 mM | 0.9652 mL | 4.8258 mL | 9.6516 mL | 24.1289 mL | |
10 mM | 0.4826 mL | 2.4129 mL | 4.8258 mL | 12.0645 mL | |
20 mM | 0.2413 mL | 1.2064 mL | 2.4129 mL | 6.0322 mL | |
50 mM | 0.0965 mL | 0.4826 mL | 0.9652 mL | 2.4129 mL | |
100 mM | 0.0483 mL | 0.2413 mL | 0.4826 mL | 1.2064 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Miglitol 72432-03-2 Others BAY-1099 BAY1099 米格列醇 inhibit BAY-m1099 BAY 1099 Inhibitor inhibitor