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Miglitol

Miglitol

产品编号 T1529   CAS 72432-03-2
别名: BAY1099, 米格列醇, BAY-m1099

Miglitol (BAY1099) 是一种口服抗糖尿病化合物,能够抑制糖复合体分解为葡萄糖。

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Miglitol Chemical Structure
Miglitol, CAS 72432-03-2
规格 价格/CNY 货期 数量
100 mg ¥ 137 现货
产品目录号及名称: Miglitol (T1529)
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.
体内活性 D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice. [1] D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age. [2] D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls. [3] D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. [4] D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. [5]
别名 BAY1099, 米格列醇, BAY-m1099
分子量 207.22
分子式 C8H17NO5
CAS No. 72432-03-2

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 20.7 mg/mL (100 mM)

DMSO: 20.7 mg/mL (100 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.8258 mL 24.1289 mL 48.2579 mL 120.6447 mL
5 mM 0.9652 mL 4.8258 mL 9.6516 mL 24.1289 mL
10 mM 0.4826 mL 2.4129 mL 4.8258 mL 12.0645 mL
20 mM 0.2413 mL 1.2064 mL 2.4129 mL 6.0322 mL
50 mM 0.0965 mL 0.4826 mL 0.9652 mL 2.4129 mL
100 mM 0.0483 mL 0.2413 mL 0.4826 mL 1.2064 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Rossi EJ, et al. FEBS J. 2006 Jun;273(12):2673-83. 2. Liu T, Liu R, Zhu L, et al. Development of a UHPLC-MS method for inhibitor screening against α-L-1, 3-fucosidase[J]. Analytical and bioanalytical chemistry. 2019 Mar;411(7):1467-1477.

文献引用

1. Liu T, Liu R, Zhu L, et al. Development of a UHPLC-MS method for inhibitor screening against α-L-1, 3-fucosidase. Analytical and bioanalytical chemistry. 2019 Mar;411(7):1467-1477.

相关化合物库

该产品包含在如下化合物库中:
临床期小分子药物库 人代谢物化合物库 NO PAINS 化合物库 FDA 上市药物库 药物功能重定位化合物库 药物片段库 Ro5类药天然产物库 抑制剂库 生物碱类天然产物库 天然产物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Miglitol 72432-03-2 Others BAY-1099 BAY1099 米格列醇 inhibit BAY-m1099 BAY 1099 Inhibitor inhibitor

 

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