首页 Metabolism Hydrogenase Metronidazole
Metronidazole
编号 T1079     别名: Flagyl, Metronidazol, Anagiardil
CAS 443-48-1     分子式 C6H9N3O3     分子量 171.16
靶点: 14-α Demethylase; Fe hydrogenase 1; NADPH nitroreductase;
Metronidazole is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
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规格 库存 单价 数量
500 mg 上海现货 345.00
1 mL * 10 mM (in DMSO) 上海现货 485.00
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生物活性

产品描述

Metronidazole is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.

靶点活性

14-α Demethylase,

Fe hydrogenase 1,

NADPH nitroreductase,

体外活性

Metronidazole is relatively inactive until it is metabolized within host or microbial cells. Metronidazole is activated when it receives an electron from ferredoxin or fla vodoxin that is reduced by POR in anaerobic or microaerophilic bacteria or luminal parasites. Metronidazole damages cells by forming protein and DNA adducts. [1] Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug is first approved as an effective treatment. The activity of metronidazole against anaerobic bowel flora has been used for prophylaxis and treatment of patients with Crohn's disease who might develop an infectious complication. Metronidazole has played an important role in anaerobic-related infections.   Metronidazole has notable effectiveness in treating anaerobic brain abscesses. [2] Metronidazole resistance tends to result from de novo mutation in the resident rdxA gene, rather than from lateral transfer of mutant rdxA (or other) genes from unrelated but Mtzr strains. Metronidazole partially inhibits growth stimulate forward mutation to rifampin resistance in rdxA(+) (Metronidazole(s)) and also in rdxA (Metronidazole(r)) H. pylori strains, and that expression of rdxA in Escherichia coli results in equivalent Mtz-induced mutation. [3] Metronidazole leads to apoptosis-like features in growing cultures of axenic B. hominis, including key morphological and biochemical features of programmed cell death (PCD), viz. nuclear condensation and nicked DNA in nucleus, reduced cytoplasmic volume, externalization of phosphatidylserine and maintenance of plasma membrane integrity with increasing permeability. [4]

体内活性

化学信息

分子量

171.16

分子式

C6H9N3O3

CAS

443-48-1

溶解度

DMSO: 32 mg/mL (187 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 5.842 ml 29.212 ml 58.425 ml
5 mM 1.168 ml 5.842 ml 11.685 ml
10 mM 0.584 ml 2.921 ml 5.842 ml
50 mM 0.117 ml 0.584 ml 1.168 ml
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