首页 GPCR/G Protein Histamine Receptor Metoprine
Metoprine
编号 T8548    
CAS 7761-45-7     分子式 C11H10Cl2N4     分子量 269.13
靶点: histamine N-methyltransferase; antifolate;
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
选择批次  
规格 库存 单价 数量
1 mg 上海现货 640.00
5 mg 上海现货 1536.00
25 mg 上海现货 4596.00
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生物活性

产品描述

Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.

靶点活性

histamine N-methyltransferase,

antifolate,

体外活性

体内活性

In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain. Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose[1].

化学信息

分子量

269.13

分子式

C11H10Cl2N4

CAS

7761-45-7

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.716 ml 18.578 ml 37.157 ml
5 mM 0.743 ml 3.716 ml 7.431 ml
10 mM 0.372 ml 1.858 ml 3.716 ml
50 mM 0.074 ml 0.372 ml 0.743 ml
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