首页 GPCR/G Protein Histamine Receptor Mequitazine
Mequitazine
编号 T4499     别名: LM-209, Virginan, Primalan, Metaplexan, Virginan, Primalan, Metaplexan, LM-209
CAS 29216-28-2     分子式 C20H22N2S     分子量 322.47
靶点:
Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist.
选择批次  
规格 库存 单价 数量
2 mg 上海现货 345.00
5 mg 上海现货 531.00
10 mg 上海现货 812.00
25 mg 上海现货 1158.00
50 mg 上海现货 1498.00
100 mg 上海现货 1998.00
1 mL * 10 mM (in DMSO) 上海现货 531.00
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生物活性

产品描述

Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist.

靶点活性

体外活性

Mequitazine is widely studied and used for allergic disorders such as hay fever and urticaria[1]. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced [2].

体内活性

Mequitazine antagonizes the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity [3]. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta [4].

化学信息

分子量

322.47

分子式

C20H22N2S

CAS

29216-28-2

溶解度

DMSO: 15 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.101 ml 15.505 ml 31.011 ml
5 mM 0.62 ml 3.101 ml 6.202 ml
10 mM 0.31 ml 1.551 ml 3.101 ml
50 mM 0.062 ml 0.31 ml 0.62 ml
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