Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mepivacaine hydrochloride (Mepivacaine HCl) 是具有局部麻醉特性的酰胺衍生物。Mepivacaine hydrochloride 与神经元细胞膜上特定的电压门控钠离子通道结合,抑制钠离子内流和膜去极化。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 115 | 现货 | ||
100 mg | ¥ 153 | 现货 | ||
200 mg | ¥ 208 | 现货 |
产品描述 | Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. |
体内活性 | 在马匹进行的测试表明,mepivacaine在相邻滑膜结构间的扩散比从先前的解剖学、乳胶注射及对比关节造影研究所假设的要广泛。[1] 超声波在减少进行膝关节镜手术的患者所需的最小有效麻醉体积(MEAV50)方面表现出色。与神经刺激相比,使用1.5% mepivacaine时可降低37%。[2] 使用3% mepivacaine提供的麻醉持续时间比带有肾上腺素的lidocaine配方在犬齿和前磨牙中更短。[3] |
激酶实验 | Phosphatase Assay: Purified bovine brain calcineurin and calmodulin are purchased. Reaction mixtures with purified enzyme contains 100 nM calcineurin, 100 nM calmodulin, and 5 μM 32P-labeled phosphopeptide, in 60 μl (total volume) of assay buffer containing 20 mM Tris (pH 8), 100 mM NaCI, 6 mM MgCl2, 0.5 mM dithiothreitol, 0.1 mg of bovine serum albumin per ml, and either 0.1 mM CaCl2 or 5 mM EGTA. Reaction mixtures with cell lysates contains 20 μl of undiluted lysate, 5 μM 32P-labeled phosphopeptide, and 40 μl of assay buffer. Where indicated, reaction mixtures contains 50 μM peptide 412 or 413 and/or 500 nM okadaic acid, a specific inhibitor of phosphatases 1 and 2A; 500 nM okadaic acid is sufficient for inhibition of Ca2+-independent phosphatases, whereas higher concentrations partially inhibit Ca2+-dependent activity as well. After 15 min at 30°C, reactions are terminated by the addition of 0.5 ml of 100 mM potassium phosphate buffer (pH 7.0) containing 5% trichloroacetic acid. Free inorganic phosphate is isolated by Dowex cation-exchange chromatography and quantitated by scintillation counting as described. |
别名 | Mepivacaine HCl, 盐酸甲哌卡因 |
分子量 | 282.81 |
分子式 | C15H22N2O·HCl |
CAS No. | 1722-62-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3 mg/mL (10.6 mM)
Ethanol: 8 mg/mL (28.28 mM)
H2O: 52 mg/mL (183.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol / H2O | 1 mM | 3.5359 mL | 17.6797 mL | 35.3594 mL | 88.3986 mL |
5 mM | 0.7072 mL | 3.5359 mL | 7.0719 mL | 17.6797 mL | |
10 mM | 0.3536 mL | 1.768 mL | 3.5359 mL | 8.8399 mL | |
Ethanol / H2O | 20 mM | 0.1768 mL | 0.884 mL | 1.768 mL | 4.4199 mL |
H2O | 50 mM | 0.0707 mL | 0.3536 mL | 0.7072 mL | 1.768 mL |
100 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL | 0.884 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mepivacaine hydrochloride 1722-62-9 Membrane transporter/Ion channel Sodium Channel regional inhibit Mepivacaine HCl Mepivacaine Na channels local infiltration Inhibitor Mepivacaine Hydrochloride Na+ channels neuronal cell depolarization anesthetic amide-type 盐酸甲哌卡因 inhibitor