首页 GPCR/G Protein Histamine Receptor Meclizine dihydrochloride
Meclizine dihydrochloride
编号 T1110     别名: NSC28728, Meclozine dihydrochloride, Meclizine 2HCl
CAS 1104-22-9     分子式 C25H27ClN2·2HCl     分子量 463.87
靶点: H1 receptor;
Meclizine hydrochloride is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
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规格 库存 单价 数量
50 mg 上海现货 405.00
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生物活性

产品描述

Meclizine hydrochloride is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

靶点活性

H1 receptor,

实验溶液

5% DMSO+95% Corn oil: 10 mg/mL

体外活性

Meclizine在体外实验中,剂量依赖性增加mCAR反式激活,激活激素受体共激活因子1与受体的结合。相反,Meclizine在来源于小鼠的只表达hCAR,不表达mCAR的肝脏细胞中,抑制hCAR转录激活和鲁米那诱导的CAR下游基因(包括细胞色素p450 单氧酶2B10、CYP3A11以及CYP1A2)的表达。Meclizine是小鼠CAR激动剂配体(组成型雄甾烷受体),人类CAR的反向激动剂。

体内活性

Meclizine以CAR依赖的方式增加小鼠CAR靶基因的表达.

细胞实验

HepG2 cells are cultured in 24-well dishes with DMEM supplemented with 10% charcoal-stripped calf serum. Cells are transfected using calcium phosphate with 100 ng of receptor expression vectors, 300 ng of luciferase reporter plasmids, and 100 ng of pSV2-β-galactosidase as internal control of transfection efficiency. Drugs are added 12 h after transfection, and cells are incubated for an additional 24 h. The cell lysate is assayed for luciferase activity and normalized to β-galactosidase activity.(Only for Reference)

细胞系: HepG2 cells

动物实验

动物模型:Mouse

化学信息

分子量

463.87

分子式

C25H27ClN2·2HCl

CAS

1104-22-9

溶解度

DMSO: 23.2 mg/mL (50 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.156 ml 10.779 ml 21.558 ml
5 mM 0.431 ml 2.156 ml 4.312 ml
10 mM 0.216 ml 1.078 ml 2.156 ml
50 mM 0.043 ml 0.216 ml 0.431 ml
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