Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mebendazole (Mebenvet) 是一种 hedgehog 抑制剂,用作驱虫药。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 332 | 现货 | ||
1 g | ¥ 415 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 415 | 现货 |
产品描述 | Mebendazole (Mebenvet) is a hedgehog inhibitor, used as an antihelminthic. |
体外活性 | mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells[2]. |
体内活性 | When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice[2]. |
细胞实验 | When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.(Only for Reference) |
别名 | 甲苯达唑, 甲苯咪唑, Telmin, Mebenvet, Vermox, Pantelmin |
分子量 | 295.29 |
分子式 | C16H13N3O3 |
CAS No. | 31431-39-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3865 mL | 16.9325 mL | 33.865 mL | 84.6625 mL |
5 mM | 0.6773 mL | 3.3865 mL | 6.773 mL | 16.9325 mL | |
10 mM | 0.3387 mL | 1.6933 mL | 3.3865 mL | 8.4663 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mebendazole 31431-39-7 Apoptosis Cytoskeletal Signaling Microbiology/Virology Microtubule Associated Parasite 甲苯达唑 甲苯咪唑 Telmin Mebenvet Inhibitor Vermox Pantelmin inhibit inhibitor