Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 720 | 5日内发货 | ||
5 mg | ¥ 1,260 | 5日内发货 | ||
25 mg | ¥ 5,380 | 6-8周 | ||
50 mg | ¥ 6,990 | 6-8周 | ||
100 mg | ¥ 11,600 | 6-8周 |
Mavorixafor trihydrochloride 的其他形式现货产品:
产品描述 | Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM). |
靶点活性 | HIV-1 (NL4.3 strain):9 nM (in PBMCs), HIV-1:26 nM (IC90, in PBMCs), HIV-1 (NL4.3 strain):1 nM (in MT-4 cells), HIV-1 (NL4.3 strain):3 nM (IC90, in MT-4 cells), [125I]-SDF-CXCR4:13 nM |
体外活性 | Mavorixafor (AMD-070) shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [1]. Mavorixafor (6.6 μM) significantly suppresses the anchorage-dependent growth, the migration and matrigel invasion of the B88-SDF-1 cells [2]. |
体内活性 | Mavorixafor (2 mg/kg, p.o.) significantly reduces the number of metastatic lung nodules in mice and lowers the expression of human Alu DNA in mice without body weight loss [2]. |
别名 | AMD-070 trihydrochloride |
分子量 | 458.86 |
分子式 | C21H30Cl3N5 |
CAS No. | 2309699-17-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (13.08 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1793 mL | 10.8966 mL | 21.7931 mL | 54.4828 mL |
5 mM | 0.4359 mL | 2.1793 mL | 4.3586 mL | 10.8966 mL | |
10 mM | 0.2179 mL | 1.0897 mL | 2.1793 mL | 5.4483 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mavorixafor trihydrochloride 2309699-17-8 Microbiology/Virology Proteases/Proteasome HIV Protease AMD-070 trihydrochloride AMD-070 AMD 070 Trihydrochloride AMD-070 Trihydrochloride AMD 070 Mavorixafor AMD070 Trihydrochloride Mavorixafor Trihydrochloride AMD070 Inhibitor inhibitor inhibit