Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMAD (Demethyldolastatin 10) 是一种有效的微管蛋白抑制剂,是抗体药物偶联物中的一种毒素有效载荷。
产品描述 | MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs). |
体外活性 | MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. The site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity when compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction. |
体内活性 | The resulting antibody-drug conjugates (ADCs) exhibited complete tumor regression in rodents. They also have an improved toxicology profile in rats. |
别名 | Monomethylauristatin D, Demethyldolastatin 10, 单甲基澳瑞他汀 D, Monomethyl Dolastatin 10 |
分子量 | 771.06 |
分子式 | C41H66N6O6S |
CAS No. | 203849-91-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24.5 mg/mL (31.77 mM), Sonification and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.2969 mL | 6.4846 mL | 12.9692 mL | 32.4229 mL |
5 mM | 0.2594 mL | 1.2969 mL | 2.5938 mL | 6.4846 mL | |
10 mM | 0.1297 mL | 0.6485 mL | 1.2969 mL | 3.2423 mL | |
20 mM | 0.0648 mL | 0.3242 mL | 0.6485 mL | 1.6211 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MMAD 203849-91-6 Cytoskeletal Signaling Microtubule Associated inhibit Monomethylauristatin D Demethyldolastatin-10 Demethyldolastatin10 Demethyldolastatin 10 Monomethyl Dolastatin-10 单甲基澳瑞他汀 D Inhibitor Microtubule/Tubulin ADC Payload Monomethyl Dolastatin10 ADC Cytotoxin Monomethyl Dolastatin 10 inhibitor