Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M8-B Hydrochloride 是一种选择性瞬时受体电位 melastatin-8 (TRPM8) 通道拮抗剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 328 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,160 | 现货 | ||
25 mg | ¥ 2,490 | 现货 | ||
50 mg | ¥ 3,970 | 现货 | ||
100 mg | ¥ 5,660 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 952 | 现货 |
产品描述 | M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist. |
体内活性 | M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures. |
动物实验 | Eight day old male Wistar rat pups were used for induction of febrile seizure.?M8 B and diazepam were injected intraperitoneally.?The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured.?In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ).?Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured[1]. |
分子量 | 432.96 |
分子式 | C22H25ClN2O3S |
CAS No. | 883976-12-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (63.52 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3097 mL | 11.5484 mL | 23.0968 mL | 57.7421 mL |
5 mM | 0.4619 mL | 2.3097 mL | 4.6194 mL | 11.5484 mL | |
10 mM | 0.231 mL | 1.1548 mL | 2.3097 mL | 5.7742 mL | |
20 mM | 0.1155 mL | 0.5774 mL | 1.1548 mL | 2.8871 mL | |
50 mM | 0.0462 mL | 0.231 mL | 0.4619 mL | 1.1548 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
M8-B Hydrochloride 883976-12-3 Membrane transporter/Ion channel TRP/TRPV Channel M8 B Hydrochloride M-8-B Hydrochloride M8B Hydrochloride Inhibitor inhibitor inhibit