Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Luzindole (N-0774) 是一种选择性褪黑素受体拮抗剂,可抑制实验性自身免疫性脑脊髓炎,有抗抑郁样活性。它优先靶向 MT2 (Mel1b),对于人 MT2 和 MT1 的 Ki 值分别为 10.2 和 158 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 628 | 现货 | ||
5 mg | ¥ 1,570 | 现货 | ||
10 mg | ¥ 2,570 | 现货 | ||
25 mg | ¥ 4,230 | 现货 | ||
50 mg | ¥ 5,900 | 现货 | ||
100 mg | ¥ 8,120 | 现货 | ||
500 mg | ¥ 16,200 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,930 | 现货 |
产品描述 | Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively. |
靶点活性 | MT2 receptor:10.2 nM(ki), MT1 receptor:158 nM(ki) |
体外活性 | Luzindole (5-10 μg/ml) suppresses antigen-specific proliferation of the MBP-reactive LV-4 T cell line[1]. |
体内活性 | Luzindole (30 mg/kg i.p.) decreases the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). Luzindole (30 mg/kg; i.p.; days 0-5) inhibits experimental autoimmune encephalomyelitis[2]. Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin[3]. The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.). |
别名 | N-乙酰-2-苄基色胺, N-0774 |
分子量 | 292.37 |
分子式 | C19H20N2O |
CAS No. | 117946-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (342.03 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4203 mL | 17.1016 mL | 34.2032 mL | 85.5081 mL |
5 mM | 0.6841 mL | 3.4203 mL | 6.8406 mL | 17.1016 mL | |
10 mM | 0.342 mL | 1.7102 mL | 3.4203 mL | 8.5508 mL | |
20 mM | 0.171 mL | 0.8551 mL | 1.7102 mL | 4.2754 mL | |
50 mM | 0.0684 mL | 0.342 mL | 0.6841 mL | 1.7102 mL | |
100 mM | 0.0342 mL | 0.171 mL | 0.342 mL | 0.8551 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Luzindole 117946-91-5 GPCR/G Protein Neuroscience Melatonin Receptor MT Receptor N0774 inhibit autoimmune anti-immobility subtype preferentially selective N 0774 Inhibitor encephalomyelitis N-乙酰-2-苄基色胺 antidepressant-like N-0774 inhibitor