Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lorediplon 是一种新型催眠药物,作为 GABAA 受体调节剂,在 α1 亚基上具有差异活性,与促进睡眠有关。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 255 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 845 | 现货 | ||
50 mg | ¥ 1,660 | 现货 | ||
100 mg | ¥ 2,470 | 现货 | ||
200 mg | ¥ 3,650 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 398 | 现货 |
产品描述 | Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep. |
体内活性 | In vivo, Lorediplon inhibits spontaneous motor activity and increases the duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity [1]. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow-wave sleep (SWS) and paradoxical sleep (PS) in mice [2]. |
分子量 | 394.42 |
分子式 | C20H15FN4O2S |
CAS No. | 917393-39-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (253.54 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5354 mL | 12.6768 mL | 25.3537 mL | 63.3842 mL |
5 mM | 0.5071 mL | 2.5354 mL | 5.0707 mL | 12.6768 mL | |
10 mM | 0.2535 mL | 1.2677 mL | 2.5354 mL | 6.3384 mL | |
20 mM | 0.1268 mL | 0.6338 mL | 1.2677 mL | 3.1692 mL | |
50 mM | 0.0507 mL | 0.2535 mL | 0.5071 mL | 1.2677 mL | |
100 mM | 0.0254 mL | 0.1268 mL | 0.2535 mL | 0.6338 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lorediplon 917393-39-6 Membrane transporter/Ion channel Neuroscience GABA Receptor γ-Aminobutyric acid Receptor inhibit Inhibitor Gamma-aminobutyric acid Receptor inhibitor