首页 GPCR/G Protein Histamine Receptor Lodoxamide
Lodoxamide
编号 T4566     别名: Lodoxamidum, Lodoxamidum
CAS 53882-12-5     分子式 C11H6ClN3O6     分子量 311.63
靶点:
Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
选择批次  
规格 库存 单价 数量
5 mg 上海现货 537.00
10 mg 上海现货 822.00
50 mg 上海现货 1962.00
100 mg 上海现货 2817.00
200 mg 上海现货 5097.00
1 mL * 10 mM (in DMSO) 上海现货 537.00
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生物活性

产品描述

Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.

靶点活性

体外活性

Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells [1]. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin [2].

体内活性

Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anaesthetized rhesus monkeys [1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation decreased microvascular permeability, and increased compliance [3].

化学信息

分子量

311.63

分子式

C11H6ClN3O6

CAS

53882-12-5

溶解度

DMSO: 15 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.209 ml 16.045 ml 32.089 ml
5 mM 0.642 ml 3.209 ml 6.418 ml
10 mM 0.321 ml 1.604 ml 3.209 ml
50 mM 0.064 ml 0.321 ml 0.642 ml
相关化合物库
本产品收录于以下化合物库中:
  • 上市药物库
  • 经典已知活性库
  • FDA 上市药物库
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