Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibition of Na+ and the Ito channel. Liriodenine also has antimuscarinic properties, the antimuscarinic characteristics are similar to those of 4-diphenylacetoxy-N-methylpiperidine (4-DAMP, smooth muscle selective M3 antagonist), it may act as a selective M3 receptor antagonist in canine tracheal smooth muscle.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 3,230 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,330 | 待询 |
产品描述 | Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibition of Na+ and the Ito channel. Liriodenine also has antimuscarinic properties, the antimuscarinic characteristics are similar to those of 4-diphenylacetoxy-N-methylpiperidine (4-DAMP, smooth muscle selective M3 antagonist), it may act as a selective M3 receptor antagonist in canine tracheal smooth muscle. |
体外活性 | The present study therefore investigated the potential antitumor effects of Liriodenine on HEp-2 human laryngocarcinoma cells in vitro and HEp-2-implanted nude mice in vivo. Liriodenine induced significant apoptosis and inhibition of cell migration in the HEp-2 cells. Furthermore, the rate of tumor growth in the HEp-2-implanted nude mice was inhibited by the administration of Liriodenine. The potential mechanism underlying the antitumor effects of Liriodenine may result from an upregulative effect upon p53 expression, which ultimately induces cellular apoptosis. By contrast, the downregulation of p53 significantly reduced the antitumor effects of Liriodenine[1] |
别名 | 鹅掌揪碱 |
分子量 | 275.26 |
分子式 | C17H9NO3 |
CAS No. | 475-75-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Liriodenine 475-75-2 Apoptosis Proteases/Proteasome p53 Caspase BCL 鹅掌揪碱 Inhibitor inhibitor inhibit