Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素,有抑制细菌DNA 旋转酶的超螺旋活性的作用,能阻止DNA 复制。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 298 | 现货 | ||
100 mg | ¥ 418 | 现货 | ||
500 mg | ¥ 553 | 现货 | ||
5 g | ¥ 798 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 460 | 现货 |
产品描述 | Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections. |
体外活性 | Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate?activity?against anaerobes.[1] Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more?active?than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant.?Levofloxacin?inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. [2] Levofloxacin?exhibits twofold greater?inhibitory?and?bactericidal?activities?than ofloxacin?against?either extracellular or intracellular tubercle bacilli.?[3] Levofloxacin?has the least?inhibitory?effect on osteoblastic cell growth, with a 50%?inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis.[4] Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells. [5] |
体内活性 | Levofloxacin 在小鼠的全身性及肾盂肾炎感染中,其疗效相当于或优于环丙沙星。Levofloxacin 在小鼠的血清和组织中达到的浓度高于环丙沙星。[2] |
别名 | Levaquin, Cravit, Tavanic, Fluoroquinolone, 左氧氟沙星, (-)-Ofloxacin |
分子量 | 361.37 |
分子式 | C18H20FN3O4 |
CAS No. | 100986-85-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (34.59 mM)
Ethanol: 2 mg/mL(5.5 mM)
H2O: 9 mg/mL (24.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol / H2O | 1 mM | 2.7672 mL | 13.8362 mL | 27.6725 mL | 69.1812 mL |
5 mM | 0.5534 mL | 2.7672 mL | 5.5345 mL | 13.8362 mL | |
DMSO / H2O | 10 mM | 0.2767 mL | 1.3836 mL | 2.7672 mL | 6.9181 mL |
20 mM | 0.1384 mL | 0.6918 mL | 1.3836 mL | 3.4591 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Levofloxacin 100986-85-4 DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic Orthopoxvirus BK Viremia Levaquin inhibit Inhibitor Cravit DNA gyrase Tavanic airway inflammation Fluoroquinolone DNA/RNA Synthesis Bacterial Ofloxacin 左氧氟沙星 (-)-Ofloxacin chronic periodontitis inhibitor