Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lerisetron 是5-HT3拮抗剂,与 5-HT3受体具有高亲和力(pKi:9.2)。它对尿烷麻醉大鼠的 5-HT 引发的反射性心率过缓具有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 558 | 现货 | ||
2 mg | ¥ 818 | 现货 | ||
5 mg | ¥ 1,370 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 3,490 | 现货 | ||
50 mg | ¥ 4,980 | 现货 | ||
100 mg | ¥ 6,890 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,250 | 现货 |
产品描述 | Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity. |
靶点活性 | 5-HT3 receptor (cell-free assay):0.81 μM |
体内活性 | showed a decrease in total clearance and distribution volume of the central compartment in old rats. The lerisetron free (unbound) fraction remained unchanged among the groups, and there were no significant differences in alpha(1)-acid glycoprotein levels. The concentration-effect relationship was best described by a sigmoid E(max) model. Since the drug concentration in plasma at half-maximal effect (EC(50)) decreased in old rats, an increased sensitivity to the effect of lerisetron in old animals could be expected. |
动物实验 | Fischer 344 rats (n = 44) were divided into three groups, depending on their age: 5, 13, and 25 months. Blood samples were collected before administration of 200 micro g/kg of lerisetron for measurements of albumin, alpha(1)-acid glycoprotein, and unbound fraction of lerisetron. The lerisetron plasma concentrations were measured by high-performance liquid chromatography. A two-compartment model was fitted to the data using the nonlinear mixed-effects computer program WinNonMix. The population analysis was performed with the complete set of the collected data, and the potential sources of variability in the population parameters were investigated. Additionally, a pharmacodynamic study was performed. The effect of lerisetron (inhibition of the von Bezold-Jarisch reflex) was evaluated in young, adult, and senescent Fischer 344 rats. |
分子量 | 292.38 |
分子式 | C18H20N4 |
CAS No. | 143257-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 53 mg/ml(181.27 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4202 mL | 17.101 mL | 34.2021 mL | 85.5052 mL |
5 mM | 0.684 mL | 3.4202 mL | 6.8404 mL | 17.101 mL | |
10 mM | 0.342 mL | 1.7101 mL | 3.4202 mL | 8.5505 mL | |
20 mM | 0.171 mL | 0.8551 mL | 1.7101 mL | 4.2753 mL | |
50 mM | 0.0684 mL | 0.342 mL | 0.684 mL | 1.7101 mL | |
100 mM | 0.0342 mL | 0.171 mL | 0.342 mL | 0.8551 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lerisetron 143257-98-1 GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Receptor Serotonin Bradycardia Inhibitor 5-hydroxytryptamine Receptor Pharmacokinetics inhibit SD rats inhibitor