store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 554 | 现货 | ||
5 mg | ¥ 913 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 983 | 现货 |
产品描述 | LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively). |
靶点活性 | mGluR3 (human):10 nM, mGluR8 (human):170 nM, mGluR2(human):2.9 nM |
体内活性 | LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 (3.0 mg/kg) reduces Dvl-2, pGSK-3α/β, and β-catenin protein levels but Dvl-1, Dvl-3, and GSK-3α/β are unaffected in both the PFC and STR. LY341495 (0.3, 1, and 3 mg/kg, i.p.) shows a lower level of discrimination in rats[1]. LY341495 has generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268[2]. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice[3]. |
分子量 | 353.37 |
分子式 | C20H19NO5 |
CAS No. | 201943-63-7 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (16.98 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8299 mL | 14.1495 mL | 28.299 mL | 70.7474 mL |
5 mM | 0.566 mL | 2.8299 mL | 5.6598 mL | 14.1495 mL | |
10 mM | 0.283 mL | 1.4149 mL | 2.8299 mL | 7.0747 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LY341495 201943-63-7 Endocrinology/Hormones Androgen Receptor LY-341495 LY 341495 Inhibitor inhibitor inhibit