Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2795050 是一种新型特异性 κ-阿片受体拮抗剂,IC50为0.72 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 859 | 现货 | ||
2 mg | ¥ 1,260 | 现货 | ||
5 mg | ¥ 1,910 | 现货 | ||
10 mg | ¥ 2,920 | 现货 | ||
25 mg | ¥ 4,830 | 现货 | ||
50 mg | ¥ 6,890 | 现货 | ||
100 mg | ¥ 9,330 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,730 | 现货 |
产品描述 | LY2795050 is a novel specific κ-Opioid Receptor antagonist (IC50: 0.72 nM). |
靶点活性 | κ opioid receptor:0.72 nM |
体外活性 | LY2795050 displays full antagonist activity and high binding affinity and selectivity for κ-opioid Receptor (Ki: 0.72 nM) [1]. |
体内活性 | In the brain, (11)C-LY2795050 displayed fast uptake kinetics (regional activity peak times of <20 min) and an uptake pattern consistent with the distribution of κ-Opioid Receptor (KOR) in primates [1]. The LY2795050 ED50 at MOR was 119 μg/kg based on a 1-site model for 11C-carfentanil. The 1-site binding model was also deemed sufficient to describe the specific binding of 11C-LY2795050 at KOR. The ED50 at KOR estimated from the 1-site model was 15.6 μg/kg. Thus, the ED50 ratio for MOR:KOR was 7.6 [2]. |
分子量 | 407.89 |
分子式 | C23H22ClN3O2 |
CAS No. | 1346133-08-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (122.58 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4516 mL | 12.2582 mL | 24.5164 mL | 61.291 mL |
5 mM | 0.4903 mL | 2.4516 mL | 4.9033 mL | 12.2582 mL | |
10 mM | 0.2452 mL | 1.2258 mL | 2.4516 mL | 6.1291 mL | |
20 mM | 0.1226 mL | 0.6129 mL | 1.2258 mL | 3.0646 mL | |
50 mM | 0.049 mL | 0.2452 mL | 0.4903 mL | 1.2258 mL | |
100 mM | 0.0245 mL | 0.1226 mL | 0.2452 mL | 0.6129 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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