Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator. |
体外活性 | LY117018 (1 μM) treatment, caused a predominantly hypophosphorylated pRb. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. LY117018 did not block E2-induced pRb phosphorylation, at lower concentrations[1]. LY117018 (1 μM; 96 hours) suppresses MCF-7 cell proliferation with an IC50 of 1 μM[2]. LY117018 inhibits oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway[3]. |
分子量 | 459.56 |
分子式 | C27H25NO4S |
CAS No. | 63676-25-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LY117018 63676-25-5 PI3K/Akt/mTOR signaling PI3K LY-117018 LY 117018 Inhibitor inhibitor inhibit