Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,970 | 5日内发货 | ||
25 mg | ¥ 9,390 | 6-8周 | ||
50 mg | ¥ 12,200 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. |
靶点活性 | LPA3:13.85 μM , LPA2:28.3 nM |
体外活性 | Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. ?LPA2 antagonist 2 inhibits LPA1 with an Imax of 59.0% at 30 μM[1].?LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. |
分子量 | 380.35 |
分子式 | C20H16N2O6 |
CAS No. | 36840-10-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (219.09 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6292 mL | 13.1458 mL | 26.2916 mL | 65.7289 mL |
5 mM | 0.5258 mL | 2.6292 mL | 5.2583 mL | 13.1458 mL | |
10 mM | 0.2629 mL | 1.3146 mL | 2.6292 mL | 6.5729 mL | |
20 mM | 0.1315 mL | 0.6573 mL | 1.3146 mL | 3.2864 mL | |
50 mM | 0.0526 mL | 0.2629 mL | 0.5258 mL | 1.3146 mL | |
100 mM | 0.0263 mL | 0.1315 mL | 0.2629 mL | 0.6573 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LPA2 antagonist 2 36840-10-5 GPCR/G Protein LPA Receptor LPA-2 antagonist 2 Inhibitor inhibitor inhibit