Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LMPTP INHIBITOR 1 dihydrochloride 是选择性的低分子量蛋白酪氨酸磷酸酶(LMPTP)抑制剂,抑制 LMPTP-A 活性的IC50为 0.8 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 723 | 现货 | ||
5 mg | ¥ 1,570 | 现货 | ||
10 mg | ¥ 2,520 | 现货 | ||
25 mg | ¥ 4,250 | 现货 | ||
50 mg | ¥ 5,930 | 现货 | ||
100 mg | ¥ 8,370 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,230 | 现货 |
产品描述 | LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. |
靶点活性 | LMPTP-A:0.8 μM |
体外活性 | LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50?of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes[1]. |
体内活性 | LMPTP inhibitor 1 dihydrochloride is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 dihydrochloride (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight[1]. |
分子量 | 517.53 |
分子式 | C28H38Cl2N4O |
CAS No. | 2310135-46-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (96.61 mM), sonification is recommended.
DMSO: 64 mg/mL (123.66 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 1.9323 mL | 9.6613 mL | 19.3226 mL | 48.3064 mL |
5 mM | 0.3865 mL | 1.9323 mL | 3.8645 mL | 9.6613 mL | |
10 mM | 0.1932 mL | 0.9661 mL | 1.9323 mL | 4.8306 mL | |
20 mM | 0.0966 mL | 0.4831 mL | 0.9661 mL | 2.4153 mL | |
50 mM | 0.0386 mL | 0.1932 mL | 0.3865 mL | 0.9661 mL | |
DMSO | 100 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4831 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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