Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LM22A-4 是特异性的tyrosine kinase receptor B 激动剂,常用于研究神经系统疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 195 | 现货 | ||
5 mg | ¥ 492 | 现货 | ||
10 mg | ¥ 872 | 现货 | ||
25 mg | ¥ 1,780 | 现货 | ||
50 mg | ¥ 3,120 | 现货 | ||
100 mg | ¥ 4,630 | 现货 | ||
500 mg | ¥ 9,670 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 547 | 现货 |
产品描述 | LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay) |
靶点活性 | TrkB:47 nM |
体外活性 | In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways[1]. |
体内活性 | Treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency[1]. |
动物实验 | Wt and Het littermates were divided into 4 groups: Wt vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.).?Each mouse was treated from 8 to 13 weeks of age.?Whole-body plethysmography was performed during week 12 and animals were subsequently killed and tissues harvested for TrkB Western blots and BDNF ELISA during week[1]. |
分子量 | 339.34 |
分子式 | C15H21N3O6 |
CAS No. | 37988-18-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (147.34 mM)
DMSO: 29 mg/mL (85.46 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.9469 mL | 14.7345 mL | 29.469 mL | 73.6724 mL |
5 mM | 0.5894 mL | 2.9469 mL | 5.8938 mL | 14.7345 mL | |
10 mM | 0.2947 mL | 1.4734 mL | 2.9469 mL | 7.3672 mL | |
20 mM | 0.1473 mL | 0.7367 mL | 1.4734 mL | 3.6836 mL | |
50 mM | 0.0589 mL | 0.2947 mL | 0.5894 mL | 1.4734 mL | |
H2O | 100 mM | 0.0295 mL | 0.1473 mL | 0.2947 mL | 0.7367 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LM22A-4 37988-18-4 Tyrosine Kinase/Adaptors Trk receptor LM-22A-4 Inhibitor Trk Receptor inhibit LM22A4 Tropomyosin related kinase receptor LM22A 4 inhibitor