首页 Cytoskeletal Signaling PAK LCH-7749944
LCH-7749944
编号 T11826     别名: GNF-PF-2356
CAS 796888-12-5     分子式 C20H22N4O2     分子量 350.41
靶点: PAK4; apoptosis;
LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM.
选择批次  
规格 库存 单价 数量
1 mg 上海现货 839.00
5 mg 上海现货 2015.00
25 mg 上海现货 5981.00
200 mg 上海现货 待询
500 mg 上海现货 待询
1 mL * 10 mM (in DMSO) 上海现货 3310.00
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生物活性

产品描述

LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor with an IC50 of 14.93 μM.

靶点活性

PAK4,14.93 μM

apoptosis,

体外活性

LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase.  LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner. LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.  LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells.

体内活性

化学信息

分子量

350.41

分子式

C20H22N4O2

CAS

796888-12-5

溶解度

DMSO: 250 mg/mL (713.45 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.854 ml 14.269 ml 28.538 ml
5 mM 0.571 ml 2.854 ml 5.708 ml
10 mM 0.285 ml 1.427 ml 2.854 ml
50 mM 0.057 ml 0.285 ml 0.571 ml
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