Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LAT1-IN-1 (BCH) 是 L 型氨基酸转运蛋白 1 的选择性竞争性抑制剂,显着抑制细胞对氨基酸的摄取和 mTOR 磷酸化,从而诱导抑制癌症生长和细胞凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 343 | 现货 | ||
50 mg | ¥ 497 | 现货 | ||
100 mg | ¥ 828 | 现货 |
产品描述 | LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1). |
体外活性 | LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.LAT1-IN-1 (1-100 mM;?3 days;?KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.?LAT1-IN-1 (30 mM;?24 and 48 hours;?KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase. |
体内活性 | LAT1-IN-1 (200 mg/kg;?intravenous injection;?daily;?for 14 days;?male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo. |
别名 | 2-氨基-2-去甲菠烷羧酸, BCH |
分子量 | 155.19 |
分子式 | C8H13NO2 |
CAS No. | 20448-79-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 12.5 mg/mL (80.55 mM), Sonification is recommended.
DMSO: < 1 mg/mL, insoluble or slightly soluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 6.4437 mL | 32.2186 mL | 64.4371 mL | 161.0929 mL |
5 mM | 1.2887 mL | 6.4437 mL | 12.8874 mL | 32.2186 mL | |
10 mM | 0.6444 mL | 3.2219 mL | 6.4437 mL | 16.1093 mL | |
20 mM | 0.3222 mL | 1.6109 mL | 3.2219 mL | 8.0546 mL | |
50 mM | 0.1289 mL | 0.6444 mL | 1.2887 mL | 3.2219 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LAT1-IN-1 20448-79-7 Apoptosis Others LAT-1-IN-1 2-氨基-2-去甲菠烷羧酸 inhibit LAT1 IN 1 LAT1IN1 BCH Inhibitor inhibitor