Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,950 | 5日内发货 | ||
25 mg | ¥ 9,390 | 10-14周 | ||
50 mg | ¥ 12,200 | 10-14周 | ||
100 mg | ¥ 18,900 | 10-14周 |
产品描述 | KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively). |
靶点活性 | ATM:3 nM |
体外活性 | Inhibition of IR-induced ATM activity by KU 59403 (1 μM) is approximately 50% in MDA-MB231 cells and >50% in HCT116 cells that have low ATM expression and activity. KU 59403 (1 μM) increases VP-16 (1 μM) cytotoxicity to a similar extent in HCT116 and HCT116-N7 cells, and in the p53 mutant SW620 cells and human breast cancer cell line, MDAMB-231, sensitisation is 11.9±4.7 and 3.8±1.8-fold respectively [1]. |
体内活性 | KU59403 with a single daily dose of 12.5 mg/kg induces an obvious sensitization. Increasing the dose of KU59403 to 25 mg/kg given twice daily causes the greatest chemo-sensitisation. In the absence of a significantly increased toxicity, It has a 3-fold increase in BMY-40481-induced tumour growth delay in both SW620 and HCT116-N7 xenografts [1]. |
分子量 | 564.72 |
分子式 | C29H32N4O4S2 |
CAS No. | 845932-30-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
KU 59403 845932-30-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR KU-59403 KU59403 Inhibitor inhibitor inhibit