Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KN-92 phosphate (KN92-H3PO4) 是 KN-93 的非活性衍生物,不能抑制 CaM 激酶活性。它可作为阐明 KN-93 的拮抗活性的对照化合物。KN-93 能够渗透细胞,是一种可逆的 CaMKII 竞争性抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 428 | 现货 | ||
2 mg | ¥ 622 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,870 | 现货 | ||
25 mg | ¥ 3,230 | 现货 | ||
50 mg | ¥ 4,720 | 现货 | ||
100 mg | ¥ 6,690 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,520 | 现货 |
产品描述 | KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
靶点活性 | CaMK II:370 nM(ki) |
体外活性 | KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. |
别名 | KN-92 磷酸盐, KN92-H3PO4 |
分子量 | 554.98 |
分子式 | C24H28ClN2O7PS |
CAS No. | 1135280-28-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (99.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8019 mL | 9.0093 mL | 18.0187 mL | 45.0467 mL |
5 mM | 0.3604 mL | 1.8019 mL | 3.6037 mL | 9.0093 mL | |
10 mM | 0.1802 mL | 0.9009 mL | 1.8019 mL | 4.5047 mL | |
20 mM | 0.0901 mL | 0.4505 mL | 0.9009 mL | 2.2523 mL | |
50 mM | 0.036 mL | 0.1802 mL | 0.3604 mL | 0.9009 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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