Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Jolkinolide B 是一种从 Euphorbia fischeriana Steud 的根中分离出来的具有生物活性的二萜。 Jolkinolide B 诱导癌细胞凋亡。 Jolkinolide B 可用于预防和治疗骨溶解的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 977 | 现货 | ||
5 mg | ¥ 2,550 | 现货 | ||
10 mg | ¥ 3,780 | 现货 | ||
25 mg | ¥ 6,120 | 现货 | ||
50 mg | ¥ 8,430 | 4-6周 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,530 | 现货 |
产品描述 | Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis. |
体外活性 | Jolkinolide B has potent anti-inflammatory, and antitumor activities. Jolkinolide B is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome c. Jolkinolide B inhibited RANKL-induced osteoclast differentiation from bone marrow macrophages (BMMs) without cytotoxicity. Furthermore, the expression of osteoclastic marker genes, such as tartrate-resistant acid phosphatase (TRAP), cathepsin K (CtsK), and calcitonin receptor (CTR), was significantly inhibited. Jolkinolide Binhibited RANKL-induced activation of NF-κB by suppressing RANKL-mediated IκBα degradation. Moreover, Jolkinolide B inhibited RANKL-induced phosphorylation of mitogen-activated protein kinases (p38, JNK, and ERK)[1]. |
分子量 | 330.42 |
分子式 | C20H26O4 |
CAS No. | 37905-08-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.3 mg/mL (10 mM), Sonification is recommended
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0265 mL | 15.1323 mL | 30.2645 mL | 75.6613 mL |
5 mM | 0.6053 mL | 3.0265 mL | 6.0529 mL | 15.1323 mL | |
10 mM | 0.3026 mL | 1.5132 mL | 3.0265 mL | 7.5661 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
猫眼草 | Euphorbia esula L.[Euphorbia lunulata Bunge] | 凉 | 苦 | 肺, 膀胱, 肝 |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Jolkinolide B 37905-08-1 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Immunology/Inflammation JAK/STAT signaling MAPK NF-Κb PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells ERK IL Receptor BCL p38 MAPK TNF NF-κB Akt Caspase PI3K JAK JNK STAT mTOR cancer inhibit human U937 Inhibitor leukemic cells inhibitor