Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JYL 1421 (SC 0030) 是 TRPV1 的拮抗剂 (IC50 = 8 nM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,350 | 5日内发货 | ||
5 mg | ¥ 2,280 | 5日内发货 | ||
25 mg | ¥ 7,930 | 6-8周 | ||
50 mg | ¥ 10,300 | 6-8周 | ||
100 mg | ¥ 16,100 | 6-8周 |
产品描述 | JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM). |
靶点活性 | TRPV1:8 nM |
体外活性 | JYL 1421(5 min) inhibits the capsaicin (330 nM)-evoked Ca2+ accumulation in a concentration-dependent manner. The inhibitory effect of the lowest concentration (5 nM) of JYL 1421 reaches the level of significance and 1 μM almost abolishes the response, only 3.1±0.65% of the first capsaicin-induced Ca2+ influx could be observed[1]. |
体内活性 | 1 and 2 μg/kg capsaicin i.v. injection evokes a transient drop of blood pressure by 47.4±4.7 and 59.6±4.2 Hgmm (n=6), respectively. Both applied doses of JYL 1421 (0.4 and 1.6 mg/kg) fail to evoke hypotension. JYL 1421 inhibits the capsaicin-induced fall in blood pressure in a dose-dependent manner as shown by the need for higher capsaicin doses to elicit the reflex hypotension after JYL 1421 administration than before treatment. Capsazepine fails to induce a significant inhibition of the capsaicin-evoked hypotension up to a dose of 2 mg/kg. Instillation of capsaicin solution (50 μL, 10 μg/mL) into the left eye of the rat evokes 12.9±1.3 wiping movements within 3 min. Pretreating the rats with JYL 1421(0.4 or 1 mg/kg i.p.) does not influence significantly the wiping behavior, but 2-5 mg/kg JYL 1421 reduces the number of wiping movements in a dose-dependent manner with an ID50 value of 4.6 mg/kg. The mean arterial pressure of untreated rats is 109.9±4.2 Hgmm (n=6)[1]. |
别名 | SC 0030 |
分子量 | 423.57 |
分子式 | C20H26FN3O2S2 |
CAS No. | 401907-26-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
JYL 1421 401907-26-4 Membrane transporter/Ion channel TRP/TRPV Channel JYL-1421 inhibit Inhibitor SC0030 JYL1421 SC 0030 TRP Channel Transient receptor potential channels SC-0030 inhibitor