生物活性
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产品描述 |
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. |
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靶点活性 |
CSF1R,13 nM TrkA,261 nM |
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体外活性 |
|
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体内活性 |
JTE-952 treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model). |
化学信息
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分子量 |
518.6 |
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分子式 |
C30H34N2O6 |
|
CAS |
1255303-54-8 |
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溶解度 |
（ < 1 mg/ml refers to the product slightly soluble or insoluble ) |
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储存条件 |
store at -80°C |
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备注 |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
配制溶液
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.928 ml | 9.641 ml | 19.283 ml |
| 5 mM | 0.386 ml | 1.928 ml | 3.857 ml |
| 10 mM | 0.193 ml | 0.964 ml | 1.928 ml |
| 50 mM | 0.039 ml | 0.193 ml | 0.386 ml |
产品操作手册
