Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-17203212 是一种竞争性 TRPV1选择性拮抗剂。它被开发用于疼痛处理的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 283 | 现货 | ||
2 mg | ¥ 395 | 现货 | ||
5 mg | ¥ 663 | 现货 | ||
10 mg | ¥ 1,160 | 现货 | ||
25 mg | ¥ 2,660 | 现货 | ||
50 mg | ¥ 4,320 | 现货 | ||
100 mg | ¥ 6,930 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 728 | 现货 |
产品描述 | JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM). |
靶点活性 | TRPV1 (human):65 nM , TRPV1 (rat):102 nM |
体内活性 | TRPV1 antagonist, JNJ-17203212, reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity.??TRPV1 is involved in the pathogenesis of visceral hypersensitivity and that JNJ-17203212 may be a potential therapeutic agent for functional bowel disorders characterized by abdominal hypersensitivity, such as irritable bowel syndrome[1]. |
动物实验 | Colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle[1]. |
分子量 | 419.32 |
分子式 | C17H15F6N5O |
CAS No. | 821768-06-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (238.48 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3848 mL | 11.9241 mL | 23.8481 mL | 59.6203 mL |
5 mM | 0.477 mL | 2.3848 mL | 4.7696 mL | 11.9241 mL | |
10 mM | 0.2385 mL | 1.1924 mL | 2.3848 mL | 5.962 mL | |
20 mM | 0.1192 mL | 0.5962 mL | 1.1924 mL | 2.981 mL | |
50 mM | 0.0477 mL | 0.2385 mL | 0.477 mL | 1.1924 mL | |
100 mM | 0.0238 mL | 0.1192 mL | 0.2385 mL | 0.5962 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
JNJ-17203212 821768-06-3 Membrane transporter/Ion channel TRP/TRPV Channel management JNJ17203212 inhibit pain migrainem Transient receptor potential channels JNJ 17203212 TRP Channel Inhibitor inhibitor