Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ 303 是有效的IKs 阻断剂,IC50为 64 nM。它浓度在 3.3 μM 时对其他心脏通道无任何影响。它诱导 QT 延长并引起无端尖端扭转型室性心动过速。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 538 | 现货 | ||
2 mg | ¥ 675 | 现货 | ||
5 mg | ¥ 913 | 现货 | ||
10 mg | ¥ 1,490 | 现货 | ||
25 mg | ¥ 3,490 | 现货 | ||
50 mg | ¥ 5,120 | 现货 | ||
100 mg | ¥ 7,260 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 888 | 现货 |
产品描述 | JNJ 303 is a potent blocker of IKs (IC50 : 64 nM). |
靶点活性 | IKs:64 nM |
体外活性 | Optical mapping was used to measure action potential durations (APDs) in the presence of the IKs blocker JNJ-303 and the IKr blocker E-4031.?JNJ-303 alone did not increase APD.?However, under isoprenaline (ISO), both the application of JNJ-303 and additional E-4031 significantly increased APD.?With JNJ-303, ISO decreased APD significantly more in the epicardium as compared to the endocardium, with subsequent application E-4031 increasing mid- and endocardial APD80 more significantly than in the epicardium.?We found that β-AR stimulation significantly augmented the effect of IKs blocker JNJ-303, in contrast to the reduced effect of IKr blocker E-4031[1]. |
分子量 | 440.98 |
分子式 | C21H29ClN2O4S |
CAS No. | 878489-28-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (24.94 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2677 mL | 11.3384 mL | 22.6768 mL | 56.6919 mL |
5 mM | 0.4535 mL | 2.2677 mL | 4.5354 mL | 11.3384 mL | |
10 mM | 0.2268 mL | 1.1338 mL | 2.2677 mL | 5.6692 mL | |
20 mM | 0.1134 mL | 0.5669 mL | 1.1338 mL | 2.8346 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
JNJ 303 878489-28-2 Membrane transporter/Ion channel Potassium Channel JNJ-303 inhibit JNJ303 Inhibitor KcsA inhibitor