首页 Microbiology/Virology HSV Isoborneol
Isoborneol
编号 T7983     别名: DL-Isoborneol
CAS 124-76-5     分子式 C10H18O     分子量 154.25
靶点: HSV-1;
Isoborneol is a monoterpene alcohol, with neuroprotective and antiviral activities
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规格 库存 单价 数量
25 mg 上海现货 190.00
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生物活性

产品描述

Isoborneol is a monoterpene alcohol, with neuroprotective and antiviral activities

靶点活性

HSV-1,

体外活性

Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1). First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption. Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines. Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data: (1) the mature fully glycosylated forms of two viral glycoproteins gB and gD were not detected when the virus was replicated in the presence of isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and isoborneol treated Vero cells, (3) isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol, a stereoisomer of isoborneol, did not inhibit HSV-1 glycosylation[1].

体内活性

化学信息

分子量

154.25

分子式

C10H18O

CAS

124-76-5

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 6.483 ml 32.415 ml 64.83 ml
5 mM 1.297 ml 6.483 ml 12.966 ml
10 mM 0.648 ml 3.241 ml 6.483 ml
50 mM 0.13 ml 0.648 ml 1.297 ml
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