首页 GPCR/G Protein Histamine Receptor Iodophenpropit dihydrobromide
Iodophenpropit dihydrobromide
编号 T15590    
CAS 145196-87-8     分子式 C15H21Br2IN4S     分子量 576.13
靶点: H3 Receptor;
Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM).
选择批次  
纯度 98.00%
规格 库存 单价 数量
100 mg 待询 待询
500 mg 待询 待询
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生物活性

产品描述

Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM).

靶点活性

H3 Receptor,0.32 nM (kd)

体外活性

Iodophenpropit suppresses 5-hydroxytryptamine (5-HT) responses (IC50 of 1.57±0.3 μM)[3]. Iodophenpropit is a very potent H3 receptor antagonist and displays only a moderate affinity for the H1 and H2 receptors [2].

体内活性

In rabbits, Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) displays obviously enhancement of total anti-sheep red blood cells (SRBC)- immunoglobulins (Igs)[4].

化学信息

分子量

576.13

分子式

C15H21Br2IN4S

CAS

145196-87-8

溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 1.736 ml 8.679 ml 17.357 ml
5 mM 0.347 ml 1.736 ml 3.471 ml
10 mM 0.174 ml 0.868 ml 1.736 ml
50 mM 0.035 ml 0.174 ml 0.347 ml
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