Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indeglitazar (PPM 204) 是 PPAR 的泛激动剂,包括亚型 alpha (α)、delta (δ) 和 gamma (γ)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 412 | 现货 | ||
5 mg | ¥ 993 | 现货 | ||
10 mg | ¥ 1,320 | 现货 | ||
25 mg | ¥ 2,570 | 现货 | ||
50 mg | ¥ 3,790 | 现货 | ||
100 mg | ¥ 5,390 | 现货 | ||
200 mg | ¥ 7,360 | 现货 | ||
500 mg | ¥ 10,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,060 | 现货 |
产品描述 | Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)). |
体外活性 | Measuring in part functional insulin sensitization capability of the cells, Indeglitazar shows an EC50 of 0.32 μM compared with Rosiglitazone, which shows an EC50 of 13 nM, in an assay of preadipocyte differentiation[1]. |
体内活性 | In Zucker rat model of diabetes, Indeglitazar (10 mg/kg; i.v.) significantly lowers the levels of glucose, HbA1C, triglycerides. In the ob/ob model of diabetes and insulin resistance, Indeglitazar significantly decreases glucose, insulin, triglycerides, and free fatty acid levels. The level of Adiponectin (day 21) is essentially unchanged, thus the observed reductions in glucose and HbA1C are achieved in an adiponectin-independent fashion[1]. |
别名 | PPM 204 |
分子量 | 389.42 |
分子式 | C19H19NO6S |
CAS No. | 835619-41-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (231.1 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5679 mL | 12.8396 mL | 25.6792 mL | 64.198 mL |
5 mM | 0.5136 mL | 2.5679 mL | 5.1358 mL | 12.8396 mL | |
10 mM | 0.2568 mL | 1.284 mL | 2.5679 mL | 6.4198 mL | |
20 mM | 0.1284 mL | 0.642 mL | 1.284 mL | 3.2099 mL | |
50 mM | 0.0514 mL | 0.2568 mL | 0.5136 mL | 1.284 mL | |
100 mM | 0.0257 mL | 0.1284 mL | 0.2568 mL | 0.642 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Indeglitazar 835619-41-5 DNA Damage/DNA Repair Metabolism PPAR PPM 204 PPM-204 PPM204 Inhibitor inhibitor inhibit