Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Imidazole ketone erastin (IKE) 是一种铁死亡的诱导剂。它对系统 Xc-胱氨酸/谷氨酸转运蛋白具有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 633 | 现货 | ||
2 mg | ¥ 932 | 现货 | ||
5 mg | ¥ 1,750 | 现货 | ||
10 mg | ¥ 2,770 | 现货 | ||
25 mg | ¥ 4,830 | 现货 | ||
50 mg | ¥ 6,880 | 现货 | ||
100 mg | ¥ 8,660 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,330 | 现货 |
产品描述 | Imidazole ketone erastin (IKE) (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter. |
体外活性 | Human astrocytoma cells (CCF-STTG1) were used, which contain the system xc?.17 Following a 2 h incubation period, glutamate released into the medium was detected fluorometrically using glutamate oxidase, horseradish peroxidase, and Amplex UltraRed. Dramatic improvement of the half-maximal inhibitory constants (IC50) for system xc? inhibition was observed for IKE (IC50: 30 nM), compared to erastin and PE [1]. |
体内活性 | In a diffuse large B cell lymphoma (DLBCL) xenograft model, IKE exerted an antitumor effect by inhibiting system xc-, leading to glutathione depletion, lipid peroxidation, and the induction of ferroptosis biomarkers [2]. |
别名 | IKE |
分子量 | 655.14 |
分子式 | C35H35ClN6O5 |
CAS No. | 1801530-11-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (152.64 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5264 mL | 7.632 mL | 15.2639 mL | 38.1598 mL |
5 mM | 0.3053 mL | 1.5264 mL | 3.0528 mL | 7.632 mL | |
10 mM | 0.1526 mL | 0.7632 mL | 1.5264 mL | 3.816 mL | |
20 mM | 0.0763 mL | 0.3816 mL | 0.7632 mL | 1.908 mL | |
50 mM | 0.0305 mL | 0.1526 mL | 0.3053 mL | 0.7632 mL | |
100 mM | 0.0153 mL | 0.0763 mL | 0.1526 mL | 0.3816 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Imidazole ketone erastin 1801530-11-9 Apoptosis Ferroptosis IKE Inhibitor inhibitor inhibit