Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Imidacloprid 是一种新烟碱类农药,广泛用于控制蔬菜,谷物,茶叶和棉花的害虫。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 293 | 现货 | ||
100 mg | ¥ 415 | 现货 | ||
200 mg | ¥ 679 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 185 | 现货 |
产品描述 | Imidacloprid is a systemic chloronicotinyl insecticide, which can be effectively used in agriculture to control pests . |
体外活性 | Three different cell models were used;?adipocytes (3T3-L1), hepatocytes (HepG2), and myotubes (C2C12).?These cells were treated with imidacloprid (0, 10, and 20 μM) for 4-6 days followed by treatment with insulin for 15 min to determine responses.?Insulin stimulated glucose uptake was reduced by imidacloprid in all three cell culture models.?Treatment with imidacloprid reduced phosphorylation of protein kinase B (AKT), one of the major regulators of insulin signaling, without changing overall AKT expression.?Subsequently, imidacloprid reduced phosphorylation of ribosomal S6 kinase (S6K), which is a downstream target of AKT and also a feed-back inhibitor of insulin signaling.?Suggest that imidacloprid could induce insulin resistance by affecting the insulin signaling cascade, particularly up-stream of AKT, in adipocytes, liver, and muscle[1]. |
分子量 | 255.66 |
分子式 | C9H10ClN5O2 |
CAS No. | 138261-41-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 300 mg/mL (1173.43 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.9114 mL | 19.5572 mL | 39.1144 mL | 97.7861 mL |
5 mM | 0.7823 mL | 3.9114 mL | 7.8229 mL | 19.5572 mL | |
10 mM | 0.3911 mL | 1.9557 mL | 3.9114 mL | 9.7786 mL | |
20 mM | 0.1956 mL | 0.9779 mL | 1.9557 mL | 4.8893 mL | |
50 mM | 0.0782 mL | 0.3911 mL | 0.7823 mL | 1.9557 mL | |
100 mM | 0.0391 mL | 0.1956 mL | 0.3911 mL | 0.9779 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Imidacloprid 138261-41-3 Others Inhibitor inhibit inhibitor