Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INH6 是一种有效的 Hec1 抑制剂,可选择性地破坏 Hec1/Nek2 相互作用并诱导染色体错位。它抑制HeLa 细胞生长的IC50值为2.4 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 255 | 现货 | ||
10 mg | ¥ 415 | 现货 | ||
25 mg | ¥ 919 | 现货 | ||
50 mg | ¥ 1,498 | 现货 | ||
100 mg | ¥ 2,820 | 现货 | ||
200 mg | ¥ 3,781 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 457 | 现货 |
产品描述 | INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment. |
靶点活性 | Hec1:2.4 μM., Nek2:2.4 μM |
体外活性 | INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis. [1] |
细胞实验 | Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.(Only for Reference) |
分子量 | 322.42 |
分子式 | C19H18N2OS |
CAS No. | 1001753-24-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 9 mg/mL (27.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (186.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 3.1015 mL | 15.5077 mL | 31.0154 mL | 77.5386 mL |
5 mM | 0.6203 mL | 3.1015 mL | 6.2031 mL | 15.5077 mL | |
10 mM | 0.3102 mL | 1.5508 mL | 3.1015 mL | 7.7539 mL | |
20 mM | 0.1551 mL | 0.7754 mL | 1.5508 mL | 3.8769 mL | |
DMSO | 50 mM | 0.062 mL | 0.3102 mL | 0.6203 mL | 1.5508 mL |
100 mM | 0.031 mL | 0.1551 mL | 0.3102 mL | 0.7754 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
INH6 1001753-24-7 Apoptosis Cytoskeletal Signaling Microtubule Associated Inhibitor INH 6 inhibit INH-6 inhibitor