Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IM156 (HL156A; HL271 acetate) 是衍生自二甲双胍的化合物,是一种强效的,具有口服活性的AMPK 激活剂。IM156 在动物模型中可缓解与年龄相关的认知下降。IM156 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂,可用于实体肿瘤的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 575 | 现货 | ||
5 mg | ¥ 1,390 | 现货 | ||
10 mg | ¥ 2,160 | 现货 | ||
25 mg | ¥ 3,690 | 现货 | ||
50 mg | ¥ 5,330 | 现货 | ||
100 mg | ¥ 7,520 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,470 | 现货 |
产品描述 | IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model [1] [2]. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which is able to be used for the research of solid tumors [3]. |
体外活性 | IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in NIH3T3 mouse fibroblast cells in a dose- and time-dependent manner [1]. IM156 does not affect the expression of key factors involved in glucose homeostasis like glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1) [1]. Western Blot Analysis [1] Cell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate. |
体内活性 | IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity [1]. IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety [2]. IM156 markedly attenuates the aging-induced decline in novel object recognition memory and spatial working memory [2]. IM156 markedly increases AMPK activation in the hippocampus of aged mice [2]. Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months) [2] Dosage: 50 mg/kg Administration: Oral administration (drinking water), for 2 months Result: Attenuated age-related cognitive decline. |
分子量 | 315.29 |
分子式 | C13H16F3N5O |
CAS No. | 1422365-93-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (87.22 mM), The compound is unstable in solution. Please use soon.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1717 mL | 15.8584 mL | 31.7168 mL | 79.2921 mL |
5 mM | 0.6343 mL | 3.1717 mL | 6.3434 mL | 15.8584 mL | |
10 mM | 0.3172 mL | 1.5858 mL | 3.1717 mL | 7.9292 mL | |
20 mM | 0.1586 mL | 0.7929 mL | 1.5858 mL | 3.9646 mL | |
50 mM | 0.0634 mL | 0.3172 mL | 0.6343 mL | 1.5858 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IM156 1422365-93-2 Apoptosis OXPHOS IM 156 IM-156 Inhibitor inhibitor inhibit