Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IDF-11774 是新型低氧诱导因子 α (HIFα)-1的抑制剂,其 IC50=3.65 μM。。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 397 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,320 | 现货 | ||
25 mg | ¥ 2,430 | 现货 | ||
50 mg | ¥ 3,790 | 现货 | ||
100 mg | ¥ 5,430 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 892 | 现货 |
产品描述 | IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM). |
靶点活性 | HIF1α:3.65 μM |
体外活性 | IDF-11774 treatment suppressed angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduced glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreased the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells. |
体内活性 | Luciferase activity and HIF-1α accumulation are strongly suppressed in the tumors of mice treated by oral administration of IDF-11774, compare with the control. |
动物实验 | When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model. |
分子量 | 368.51 |
分子式 | C23H32N2O2 |
CAS No. | 1429054-28-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (162.82 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7136 mL | 13.5682 mL | 27.1363 mL | 67.8408 mL |
5 mM | 0.5427 mL | 2.7136 mL | 5.4273 mL | 13.5682 mL | |
10 mM | 0.2714 mL | 1.3568 mL | 2.7136 mL | 6.7841 mL | |
20 mM | 0.1357 mL | 0.6784 mL | 1.3568 mL | 3.392 mL | |
50 mM | 0.0543 mL | 0.2714 mL | 0.5427 mL | 1.3568 mL | |
100 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.6784 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IDF-11774 1429054-28-3 Angiogenesis Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF inhibit HIF-PH IDF 11774 Hypoxia-inducible factors HIFs IDF11774 Inhibitor inhibitor